The bottom line in these and all other “nerve” supplements is that there is no good clinical data to support the claims they make. Some of them take supplements that have shown benefit in the dish on nerve cells or even in animals but no randomized blinded clinical trials have shown any benefit. Unless you are deficient in a vitamin, there is no no need to take extra supplements. Just eat a healthy balanced diet. 

 One has to be extra cautious of taking extra supplements/vitamins. Sometimes too much of a good thing is bad. For example we learned that extra Vitamin E, a potent anti-oxidant that was supposed to reduce cancer risk, actually increases it in a very large Scandinavian study. Similarly, too much vitamin B6 can be toxic to nerves. These nutritional supplements are unfortunately the “snake-oil” of the 20th and 21st century. I wish a cure to PN was so easy. 

Best wishes for happy holidays and New Year to everyone. 

Ahmet Hoke M.D., Ph.D. FRCPC
Professor, Neurology and Neuroscience
Director, Neuromuscular Division
Editor-in-Chief, Experimental Neurology

Johns Hopkins School of Medicine
855 N. Wolfe St., Rangos 248
Baltimore, MD, 21205
Phone: 1-410-955-2227 (Office)
Phone: 1-410-955-3794 (Laboratory)
Fax: 1-410-502-5459


Dr Ahmet Hoke studied supplements and arrived at this conclusion:

From Joe Korzelik

Page 1 of 4

Research on Scrambler (Calmare) Therapy from Joe Korzelik:

During my research I came across a treatment which shows a

lot of promise for both adults and children. It is called Scrambler Therapy {ST}

(sometimes referred as Calmare Therapy).

What has me so excited is that it is FDA approved,

 and can be covered by insurance and Medicare. I will

 get into the insurance in a bit.

 ST is totally different than the TENS Device. ST 

 changes pain perception by sending info from the 

 C-fibers of cells to the brain. It provides electro-

 stimulation with surface electrodes placed surrounding

 the pain area in order to replace "pain" signals with "no

 pain" signals. It is noninvasive and has no side effects.

 Some patients who have sensitive skin develop a rash

 on the area where the surface electrode pads were

 placed but it goes away within a few days.

 ST was created by a guy in Rome, Italy in order to fill

 the void of pharmaceutical therapies and from the 

 beginning his goal was to bridge the gap of ineffective

 therapy for neuropathic and oncologic pain.

 Success rates of total pain relief has been 90% in best

 cases to 60% in worst cases.

 It has been in use in public hospitals throughout Italy

 since the 90s.

 Its main indications for use are:

       - chronic neuropathy pain

       - chemo induced PN

       - failed back surgery

       - sciatic and lumbar pain

       - plus 3 other conditions

    It should be the 1st line of treatment before drugs, etc.

    but that is not always practical because exposure has

    been limited. It can only be used by MDs and DOs.

    It is considered a biophysical treatment and designed

    to only treat neuropathic pain. ST s also has been effective

    in treating Allodynia, which is the medical term for super

    sensitivity of the surface skin. An example is when bed 

    sheets feel like bricks on your feet.

Page 2 of 4   

First time patients usually require 10 sessions over a

two week period lasting about 45 minutes. Sometimes

less sessions are required depending on results. Relief

for first time users usually last 3 to 9 months. After

pain returns you go back for 2 or 3 sessions. As time 

goes on, the pain relief lasts longer and longer so that

you do not require treatment as often. In rare occasions

pain never returns.

 In cases where a child is involved or when an 

 adult is involved who is unable to communicate levels

 of pain before and during treatment, then a doctor can

 prescribe ST if he/she feels that it could be helpful. This

 is referred to as "Off Label Use" and a doctor can explain

 that to you.

 More than 200 patients with Chemo Induced PN treated

 with ST has experienced relief according to Charles L.

 Loprinzi, who is the Regis Professor of breast cancer

 research at Mayo Clinic. He published a paper and is 

 aware of 19 other published reports involving more than

 800 patients. Mayo and John Hopkins have connected

 several trials. 

Currently, 14 US military hospitals offer ST. 15 to 30

 public hospitals in the USA also offer it. There are

 more than 30 in Italy and even more in South Korea.

 Currently, a medical center in Boise, ID and Long 

 Beach, CA. are certified by the inventor. The one in Long

 Beach is run by a female oncologist. The University of

 Virginia also has experienced good results.

  It should also be noted that the Mayo team went to Rome

  to be trained by the inventor.

 The 1st Canadian facility is set to open in Vancouver, BC.

  80% of patients receiving ST would recommend it.

  Each treatment session costs between $200-$500 with

  an average of $350. During my research, I saw that at 

  least 21 big name insurance companies have paid 

  benefits for ST. You must call your carrier and talk to

  a "live" person and tell that person that the CPT code

  is 0278T. It will be referenced under Scrambler Therapy

  or Calmare Therapy. You will most likely be informed

  that it is not covered. You then have your doctor write

Page 3 of 4

a "Letter of Medical Necessity". You may have to appeal

more than once. Insurance carriers get very few requests

to cover ST so they are not very motivated to cover it. So

be persistent. Once they notice that they

no longer are having to cover expensive drugs or other

types of therapies, the realization that money is being

saved changes their minds.

Some carriers want you to try "TENS" because of cost

factors. It is like trying a generic drug before a more

expensive one. You can ask your doctor to work around

that obstacle.

If you have Medicare, they always want "clinical data".

Your doctor can get Medicare that info. 

I read that it is very important that the surface

electrodes be placed in the proper positions in order to

maximize effectiveness of treatment. The training 

section refers to this as "treatment execution''. Some

providers of service have not gone for training by the

inventor so it is recommended that you be treated by

one who has been trained under him. However, this is

not always practical because not everyone can afford

to travel to Boise or Long Beach. Therefore, it is very,

very important that you ask your ST doctor about how

he/she administers treatment.


For those in the Chicago area, there is a

treatment center there. I spoke with Richard Erickson

for 1 hour and 10 min regarding ST. He is with Delta International

Services and Logistics in Houston, TX. That company

handles ST in the USA. He is very informative and can get

you all the info you need about getting a provider for

you based upon the area where you live and what 

questions you need to ask the provider of service.

You can obtain further info about Scrambler Therapy

by visiting web sites under that name. A good place to

start would be the following:

     Advance Pain Solutions, Inc.

     6419 Hirondel St.

     Houston, TX 77087

     Attn: Richard Erickson

Page 4 of 4


cell- 406-249-0424


web site- and

Note- Advance Pain is somehow affiliated with Delta 

 International. I did not want you to get confused

because I referred to him as being with Delta when

 1st referenced his name.

 Doctor Charles L. Loprinzi at the Mayo Clinic